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Lemon, C.M.* ; Karnas, E.* ; Han, X.* ; Bruns, O.T. ; Kempa, T.J.* ; Fukumura, D.* ; Bawendi, M.G.* ; Jain, R.K.* ; Duda, D.G.* ; Nocera, D.G.*

Micelle-encapsulated quantum dot-porphyrin assemblies as in vivo two-photon oxygen sensors.

J. Am. Chem. Soc. 137, 9832-9842 (2015)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Micelles have been employed to encapsulate the supramolecular assembly of quantum dots with palladium(II) porphyrins for the quantification of O2 levels in aqueous media and in vivo. Förster resonance energy transfer from the quantum dot (QD) to the palladium porphyrin provides a means for signal transduction under both one- and two-photon excitation. The palladium porphyrins are sensitive to O2 concentrations in the range of 0-160 Torr. The micelle-encapsulated QD-porphyrin assemblies have been employed for in vivo multiphoton imaging and lifetime-based oxygen measurements in mice with chronic dorsal skinfold chambers or cranial windows. Our results establish the utility of the QD-micelle approach for in vivo biological sensing applications.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 0002-7863
e-ISSN 1520-5126
Journal Journal of the American Chemical Society
Quellenangaben Volume: 137, Issue: 31, Pages: 9832-9842 Article Number: , Supplement: ,
Publisher American Chemical Society (ACS)
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Helmholtz Pioneer Campus (HPC)