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Chen, O.* ; Riedemann, L.* ; Etoc, F.* ; Herrmann, H.* ; Coppey, M.* ; Barch, M.* ; Farrar, C.T.* ; Zhao, J.* ; Bruns, O.T. ; Wei, H.* ; Guo, P.* ; Cui, J. ; Jensen, R.* ; Chen, Y.* ; Harris, D.K.* ; Cordero, J.M.* ; Wang, Z.* ; Jasanoff, A.* ; Fukumura, D.* ; Reimer, R.* ; Dahan, M.* ; Jain, R.K.* ; Bawendi, M.G.*

Magneto-fluorescent core-shell supernanoparticles.

Nat. Commun. 5:5093 (2014)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Magneto-fluorescent particles have been recognized as an emerging class of materials that exhibit great potential in advanced applications. However, synthesizing such magneto-fluorescent nanomaterials that simultaneously exhibit uniform and tunable sizes, high magnetic content loading, maximized fluorophore coverage at the surface and a versatile surface functionality has proven challenging. Here we report a simple approach for co-assembling magnetic nanoparticles with fluorescent quantum dots to form colloidal magneto-fluorescent supernanoparticles. Importantly, these supernanoparticles exhibit a superstructure consisting of a close-packed magnetic nanoparticle 'core', which is fully surrounded by a 'shell' of fluorescent quantum dots. A thin layer of silica coating provides high colloidal stability and biocompatibility, and a versatile surface functionality. We demonstrate that after surface pegylation, these silica-coated magneto-fluorescent supernanoparticles can be magnetically manipulated inside living cells while being optically tracked. Moreover, our silica-coated magneto-fluorescent supernanoparticles can also serve as an in vivo multi-photon and magnetic resonance dual-modal imaging probe.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2014
HGF-reported in Year 2014
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 5, Issue: , Pages: , Article Number: 5093 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Helmholtz Pioneer Campus (HPC)
DOI 10.1038/ncomms6093
PubMed ID 25298155
Erfassungsdatum 2019-01-16
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