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Open Access Green as soon as Postprint is submitted to ZB.
Compact zwitterion-coated iron oxide nanoparticles for in vitro and in vivo imaging.
Integr. Biol. 5, 108-114 (2013)
We have recently developed compact and water-soluble zwitterionic dopamine sulfonate (ZDS) ligand coated superparamagnetic iron oxide nanoparticles (SPIONs) for use in various biomedical applications. The defining characteristics of ZDS-coated SPIONs are small hydrodynamic diameters, low non-specific interactions with fetal bovine serum, the opportunity for specific labeling, and stability with respect to time, pH, and salinity. We report here on the magnetic characterization of ZDS-coated SPIONs and their in vitro and in vivo performance relative to non-specific interactions with HeLa cells and in mice, respectively. ZDS-coated SPIONs retained the superparamagnetism and saturation magnetization (M(s)) of as-synthesized hydrophobic SPIONs, with M(s) = 74 emu g(-1) [Fe]. Moreover, ZDS-coated SPIONs showed only small non-specific uptake into HeLa cancer cells in vitro and low non-specific binding to serum proteins in vivo in mice.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
1757-9694
e-ISSN
1757-9708
Journal
Integrative biology
Quellenangaben
Volume: 5,
Issue: 1,
Pages: 108-114
Publisher
Royal Society of Chemistry (RSC)
Publishing Place
Cambridge
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Pioneer Campus (HPC)