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A highly effective, nontoxic T1 MR contrast agent based on ultrasmall PEGylated iron oxide nanoparticles.
Nano Lett. 9, 4434-4440 (2009)
In this study we systematically developed a potential MR T(1) contrast agent based on very small PEGylated iron oxide nanoparticles. We adjusted the size of the crystalline core providing suitable relaxometric properties. In addition, a dense and optimized PEG coating provides high stability under physiological conditions together with low cytotoxicity and low nonspecific phagocytosis into macrophage cells as a part of the reticulo endothelial system at biologically relevant concentrations. The as developed contrast agent has the lowest r(2)/r(1) ratio (2.4) at 1.41 T reported so far for PEGylated iron oxide nanoparticles as well as a r(1) relaxivity (7.3 mM(-1) s(-1)) that is two times higher compared to that of Magnevist as a typical T(1) contrast agent based on gadolinium as a clinical standard.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
Publication Year
2009
HGF-reported in Year
2009
ISSN (print) / ISBN
1530-6984
e-ISSN
1530-6992
Journal
Nano Letters
Quellenangaben
Volume: 9,
Issue: 12,
Pages: 4434-4440
Publisher
American Chemical Society (ACS)
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Pioneer Campus (HPC)
PubMed ID
19799448
Erfassungsdatum
2019-01-16