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Martinez Jimenez, C.P. ; Eling, N.* ; Chen, H.-C* ; Vallejos, C.A.* ; Kolodziejczyk, A.A.* ; Connor, F.* ; Stojic, L.* ; Rayner, T.F.* ; Stubbington, M.J.T.* ; Teichmann, S.A.* ; de la Roche, M.* ; Marioni, J.C.* ; Odom, D.T.*

Aging increases cell-to-cell transcriptional variability upon immune stimulation.

Science 355, 1433-1436 (2017)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Aging is characterized by progressive loss of physiological and cellular functions, but the molecular basis of this decline remains unclear. We explored how aging affects transcriptional dynamics using single-cell RNA sequencing of unstimulated and stimulated naïve and effector memory CD4 T cells from young and old mice from two divergent species. In young animals, immunological activation drives a conserved transcriptomic switch, resulting in tightly controlled gene expression characterized by a strong up-regulation of a core activation program, coupled with a decrease in cell-to-cell variability. Aging perturbed the activation of this core program and increased expression heterogeneity across populations of cells in both species. These discoveries suggest that increased cell-to-cell transcriptional variability will be a hallmark feature of aging across most, if not all, mammalian tissues.
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Publication type Article: Journal article
Document type Review
Corresponding Author
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Journal Science
Quellenangaben Volume: 355, Issue: 6332, Pages: 1433-1436 Article Number: , Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Helmholtz Pioneer Campus (HPC)