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Open Access Green as soon as Postprint is submitted to ZB.
The mechanisms shaping the single-cell transcriptional landscape.
Curr. Opin. Genet. Dev. 37, 27-35 (2016)
Recent technological and computational advances in understanding the transcriptional and chromatin features of single cells have begun answering longstanding questions in the extent and impact of biological heterogeneity. Here, we outline the intrinsic and extrinsic mechanisms that underlie the transcriptional and functional diversity within superficially homogeneous populations, and we discuss how fascinating new studies have afforded novel insight into each mechanism. The studies are chosen in part to include initial reports of novel functional genomics tools where the eventual applications will clearly have profound impact on our understanding the dynamics of cell-to-cell transcriptional variation-from individual cells to whole organisms.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0959-437X
e-ISSN
1879-0380
Quellenangaben
Volume: 37,
Pages: 27-35
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Pioneer Campus (HPC)