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Martin, L.* ; Meier, M. ; Lyons, S.M.* ; Sit, R.V.* ; Marzluff, W.F.* ; Quake, S.R.* ; Chang, H.Y.*

Systematic reconstruction of RNA functional motifs with high-throughput microfluidics.

Nat. Methods 9, 1192-1194 (2012)

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We present RNA-mechanically induced trapping of molecular interactions (RNA-MITOMI), a microfluidic platform that allows integrated synthesis and functional assays for programmable RNA libraries. The interaction of a comprehensive library of RNA mutants with stem-loop-binding protein precisely defined the RNA structural and sequence features that govern affinity. The functional motif reconstructed in a single experiment on our platform uncovers new binding specificities and enriches interpretation of phylogenetic data.

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