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Icks, A.* ; Haastert, B.* ; Gandjour, A.* ; John, J.* ; Löwel, H. ; Holle, R. ; Giani, G.* ; Rathmann, W.*

Cost-effectiveness analysis of different screening procedures for type 2 diabetes.

Diabetes Care 27, 2120-2128 (2005)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
OBJECTIVE — To compare the cost-effectiveness of different type 2 diabetes screening strat- egies using population-based data (KORA Survey; Augsburg, Germany; subjects aged 55–74 years), including participation data. RESEARCH DESIGN AND METHODS — The decision analytic model, which had a time horizon of 1 year, used the following screening strategies: fasting glucose testing, the oral glucose tolerance test (OGTT) following fasting glucose testing in impaired fasting glucose (IFG) (fasting glucose  OGTT), OGTT only, and OGTT if HbA 1c was  5.6% (HbA 1c  OGTT), all with or without first-step preselection ( p ). The main outcome measures were costs (in Euros), true-positive type 2 diabetic cases, incremental cost-effectiveness ratios (ICERs), third-party payers, and societal perspectives. RESULTS — After dominated strategies were excluded, the OGTT and HbA 1c  OGTT from the perspective of the statutory health insurance remained, as did fasting glucose  OGTT and HbA 1c  OGTT from the societal perspective. OGTTs ( € 4.90 per patient) yielded the lowest costs from the perspective of the statutory health insurance and fasting glucose  OGTT ( € 10.85) from the societal perspective. HbA 1c  OGTT was the most expensive ( € 21.44 and € 31.77) but also the most effective (54% detected cases). ICERs, compared with the next less effective strategies, were € 771 from the statutory health insurance and € 831 from the societal perspective. In the Monte Carlo analysis, dominance relations remained unchanged in 100 and 68% (statutory health insurance and societal perspective, respectively) of simulated populations. CONCLUSIONS — The most effective screening strategy was HbA 1c combined with OGTT because of high participation. However, costs were lower when screening with fasting glucose tests combined with OGTT or OGTT alone. The decision regarding which is the most favorable strategy depends on whether the goal is to identify a high number of cases or to incur lower costs at reasonable effectiveness.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 0149-5992
e-ISSN 1935-5548
Journal Diabetes Care
Quellenangaben Volume: 27, Issue: 9, Pages: 2120-2128 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, Va.
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)