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Karlsson Linnér, R.* ; Biroli, P.* ; Kong, E.* ; Meddens, S.F.W.* ; Wedow, R.* ; Fontana, M.A.* ; Lebreton, M.* ; Tino, S.P.* ; Abdellaoui, A.* ; Hammerschlag, A.R.* ; Nivard, M.G.* ; Okbay, A.* ; Rietveld, C.A.* ; Timshel, P.N.* ; Trzaskowski, M.* ; Vlaming, R.d.* ; Zünd, C.L.* ; Bao, Y.* ; Buzdugan, L.* ; Caplin, A.H.* ; Chen, C.Y.* ; Eibich, P.* ; Fontanillas, P.* ; Gonzalez, J.R.* ; Joshi, P.K.* ; Karhunen, V.* ; Kleinman, A.* ; Levin, R.Z.* ; Lill, C.M.* ; Meddens, G.A.* ; Muntané, G.* ; Sanchez-Roige, S.* ; Rooij, F.J.v.* ; Taskesen, E.* ; Wu, Y.* ; Zhang, F.* ; 23and Me Research Team* ; eQTLGen Consortium (Prokisch, H. ; Schramm, K.) ; International Cannabis Consortium* ; Social Science Genetic Association Consortium (Baumbach, C. ; Meisinger, C. ; Meitinger, T. ; Strauch, K. ; Gieger, C.) ; Auton, A.* ; Boardman, J.D.* ; Clark, D.W.* ; Conlin, A.* ; Dolan, C.C.* ; Fischbacher, U.* ; Groenen, P.J.F.* ; Mullan Harris, K.* ; Hasler, G.* ; Hofman, A.* ; Ikram, M.A.* ; Jain, S.* ; Karlsson, R.* ; Kessler, R.C.* ; Kooyman, M.* ; MacKillop, J.* ; Männikkö, M.* ; Morcillo-Suarez, C.* ; McQueen, M.B.* ; Schmidt, K.M.* ; Smart, M.C.* ; Sutter, M.* ; Thurik, A.R.* ; Uitterlinden, A.G.* ; White, J.* ; de Wit, H.* ; Yang, J.* ; Bertram, L.* ; Boomsma, D.I.* ; Esko, T.* ; Fehr, E.* ; Hinds, D.A.* ; Johannesson, M.* ; Kumari, M.* ; Laibson, D.* ; Magnusson, P.K.E.* ; Meyer, M.N.* ; Navarro, A.* ; Palmer, A.A.* ; Pers, T.H.* ; Posthuma, D.* ; Schunk, D.* ; Stein, M.B,* ; Svento, R.* ; Tiemeier, H.* ; Timmers, P.R.H.J.* ; Turley, P.* ; Ursano, R.J.* ; Wagner, G.G.* ; Wilson, J.F.* ; Gratten, J.* ; Lee, J.J.* ; Cesarini, D.* ; Benjamin, D.J.* ; Koellinger, P.D.* ; Beauchamp, J.P.*

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.

Nat. Genet. 51, 245-257 (2019)
Postprint DOI
Open Access Green
Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated (vertical bar(r) over cap (g)vertical bar similar to 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Gender-differences; Gwas; Determinants; Preferences; Personality; Ld
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 51, Issue: 2, Pages: 245-257 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Human Genetics (IHG)
Institute of Neurogenomics (ING)
Institute of Epidemiology II (EPI2)
Independent Research Group Clinical Epidemiology (KEPI)
Institute of Genetic Epidemiology (IGE)