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Ovsepian, S.V.

The dark matter of the brain.

Brain Struct. Funct. 224, 973–983 (2019)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The bulk of brain energy expenditure is allocated for maintenance of perpetual intrinsic activity of neurons and neural circuits. Long-term electrophysiological and neuroimaging studies in anesthetized and behaving animals show, however, that the great majority of nerve cells in the intact brain do not fire action potentials, i.e., are permanently silent. Herein, I review emerging data suggesting massive redundancy of nerve cells in mammalian nervous system, maintained in inhibited state at high energetic costs. Acquired in the course of evolution, these collections of dormant neurons and circuits evade routine functional undertakings, and hence, keep out of the reach of natural selection. Under penetrating stress and disease, however, they occasionally switch in active state and drive a variety of neuro-psychiatric symptoms and behavioral abnormalities. The increasing evidence for widespread occurrence of silent neurons warrants careful revision of functional models of the brain and entails unforeseen reserves for rehabilitation and plasticity.
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Publication type Article: Journal article
Document type Review
Keywords Silent Neurons ; Brain Evolution ; Fmri ; Synchronous Activity ; Schizophrenia ; Disinhibition ; Neuronal Plasticity; Odor Representations; Pyramidal Cells; Steady-state; Sparse; Inhibition; Neurons; Connectivity; Cortex; Schizophrenia; Construction
Language
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 1863-2653
e-ISSN 1863-2661
Journal Brain Structure & Function
Quellenangaben Volume: 224, Issue: 3, Pages: 973–983 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Berlin ; Heidelberg
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505500-001
DOI 10.1007/s00429-019-01835-7
WOS ID WOS:000467032400001
Scopus ID 85060214991
PubMed ID 30659350
Erfassungsdatum 2019-02-28
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