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Hilger, C.* ; Fischer, J.* ; Wölbing, F.* ; Biedermann, T.

Role and mechanism of galactose-alpha-1,3-galactose in the elicitation of delayed anaphylactic reactions to red meat.

Curr. Allergy Asthma Rep. 19:3 (2019)

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	Open Access Gold (Paid Option)

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Purpose of ReviewThe alpha-Gal (-Gal) syndrome is characterized by the presence of IgE antibodies directed at the carbohydrate galactose-alpha-1,3-galactose (-Gal). In this article, we review the presence of -Gal in food and non-food sources; we discuss the evolutionary context of the antibody response to -Gal and highlight immune responses to -Gal and other carbohydrates.Recent findingsIgE antibodies have been associated with delayed allergy to red meat. In addition to food, drugs, and other products of animal origin are increasingly perceived as a risk for patients sensitized to -Gal. The link between tick bites and anti--Gal IgE-antibody production that has been established first by epidemiological studies has now been confirmed in mouse models.SummaryThe anti--Gal immune response is complex and characterized by a unique feature. IgM and IgG antibodies have been found to confer protection against pathogens whereas the IgE-response to -Gal is detrimental and causes severe reactions upon exposure to mammalian meat and other products.

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Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Alpha-gal ; Carbohydrate ; Food Allergy ; Red Meat Allergy ; Tick; Natural Anti-gal; Forest Service Employees; Gene Knockout Mice; Alpha-gal; Ige Antibodies; Mammalian Meat; Tick Bites; I Sensitization; Immediate-type; Human Serum

ISSN (print) / ISBN 1529-7322

e-ISSN 1534-6315

Journal Current Allergy and Asthma Reports

Quellenangaben Volume: 19, Issue: 1, Article Number: 3

Publisher Current Science Inc.

Publishing Place 400 Market Street, Ste 700, Philadelphia, Pa 19106 Usa

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute for Allergy Research (IAF)