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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Lack of association between neuropeptide S receptor 1 gene (NPSR1) and eczema in five European populations.
Acta Derm.-Venereol. 89, 115-121 (2009)
Eczema is often associated with development of allergic asthma. The Neuropeptide S Receptor 1 (NPSR1) gene has previously been associated with asthma and elevated serum IgE levels. The aim of this study was to investigate a potential association between the NPSR1 gene and eczema in patients and healthy individuals from five different populations in Western Europe, in total 6275 individuals. Seven single nucleotide polymorphisms previously associated with allergic asthma were genotyped. The protein expression of NPSR1 in the skin was studied using immunohistochemistry in six eczema patients and eight healthy individuals. No association was found between eczema and the seven single nucleotide polymorphisms in NPSR1 in any of the populations, either independently or in combinations. In addition, no difference was detected in epidermal NPSR1 expression between eczema patients and healthy individuals. These results strongly suggest that NPSR1 is not involved in the pathogenesis of eczema.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
atopic dermatitis; eczema; genetic association; G protein-coupled receptor for asthma susceptibility; neuropeptide S receptor 1; protein-coupled receptor; atopy patch test; asthma; dermatitis; susceptibility; polymorphism; haplotypes; linkage; allergy; traits;
ISSN (print) / ISBN
0001-5555
e-ISSN
1651-2057
Journal
Acta Dermato-Venereologica
Quellenangaben
Volume: 89,
Issue: 2,
Pages: 115-121
Publisher
Acta Dermato-Venereologica
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)