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Fountain, M.D.* ; Oleson, D.S.* ; Rech, M.E.* ; Segebrecht, L.* ; Hunter, J.V.* ; McCarthy, J.M.* ; Lupo, P.J.* ; Holtgrewe, M.* ; Moran, R.* ; Rosenfeld, J.A.* ; Isidor, B.* ; Le Caignec, C.* ; Saenz, M.S.* ; Pedersen, R.C.* ; Morgan, T.M.* ; Pfotenhauer, J.P.* ; Xia, F.* ; Bi, W.* ; Kang, S.H.L.* ; Patel, A.* ; Krantz, I.D.* ; Raible, S.E.* ; Smith, W.* ; Cristian, I.* ; Torti, E.* ; Juusola, J.* ; Millan, F.* ; Wentzensen, I.M.* ; Person, R.E.* ; Küry, S.* ; Bézieau, S.* ; Uguen, K.* ; Férec, C.* ; Munnich, A.* ; van Haelst, M.* ; Lichtenbelt, K.D.* ; van Gassen, K.* ; Hagelstrom, T.* ; Chawla, A.* ; Perry, D.L.* ; Taft, R.J.* ; Jones, M.* ; Masser-Frye, D.* ; Dyment, D.* ; Venkateswaran, S.* ; Li, C.* ; Escobar, L.F.* ; Horn, D.* ; Spillmann, R.C.* ; Peña, L.* ; Wierzba, J.* ; Strom, T.M. ; Parenti, I.* ; Kaiser, F.J.* ; Ehmke, N.* ; Schaaf, C.P.*

Pathogenic variants in USP7 cause a neurodevelopmental disorder with speech delays, altered behavior, and neurologic anomalies.

Genet. Med. 21, 1797-1807 (2019)

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Purpose: Haploinsufficiency of USP7, located at chromosome 16p13.2, has recently been reported in seven individuals with neurodevelopmental phenotypes, including developmental delay/intellectual disability (DD/ID), autism spectrum disorder (ASD), seizures, and hypogonadism. Further, USP7 was identified to critically incorporate into the MAGEL2-USP7-TRIM27 (MUST), such that pathogenic variants in USP7 lead to altered endosomal Factin polymerization and dysregulated protein recycling.Methods: We report 16 newly identified individuals with heterozygous USP7 variants, identified by genome or exome sequencing or by chromosome microarray analysis. Clinical features were evaluated by review of medical records. Additional clinical information was obtained on the seven previously reported individuals to fully elucidate the phenotypic expression associated with USP7 haploinsufficiency.Results: The clinical manifestations of these 23 individuals suggest a syndrome characterized by DD/ID, hypotonia, eye anomalies, feeding difficulties, GERD, behavioral anomalies, and ASD, and more specific phenotypes of speech delays including a nonverbal phenotype and abnormal brain magnetic resonance image findings including white matter changes based on neuroradiologic examination.Conclusion: The consistency of clinical features among all individuals presented regardless of de novo USP7 variant type supports haploinsufficiency as a mechanism for pathogenesis and refines the clinical impact faced by affected individuals and caregivers.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Usp7 ; Neurodevelopment ; Speech Delay ; White Matter Paucity ; Corpus Callosum Thinning; Prader-willi-syndrome; Corpus-callosum; Children; Mutations; Abnormalities; Hausp; P53

ISSN (print) / ISBN 1530-0366

e-ISSN 1098-3600

Journal Genetics in Medicine

Quellenangaben Volume: 21, Issue: 8, Pages: 1797-1807

Publisher Lippincott Williams & Wilkins

Publishing Place Baltimore, Md.

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Human Genetics (IHG)