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Kainz, W.* ; Neufeld, E.* ; Bolch, W.E.* ; Graff, C.G.* ; Kim, C.H.* ; Kuster, N.* ; Lloyd, B.* ; Morrison, T.* ; Segars, P.* ; Yeom, Y.S.* ; Zankl, M. ; Xu, X.G.* ; Tsui, B.M.W.*

Advances in computational human phantoms and their applications in biomedical engineering - A topical review.

IEEE TRPMS 3, 1-23 (2019)
Postprint DOI PMC
Open Access Green
Over the past decades, significant improvements have been made in the field of computational human phantoms (CHPs) and their applications in biomedical engineering. Their sophistication has dramatically increased. The very first CHPs were composed of simple geometric volumes, e.g., cylinders and spheres, while current CHPs have a high resolution, cover a substantial range of the patient population, have high anatomical accuracy, are poseable, morphable, and are augmented with various details to perform functionalized computations. Advances in imaging techniques and semi-automated segmentation tools allow fast and personalized development of CHPs. These advances open the door to quickly develop personalized CHPs, inherently including the disease of the patient. Because many of these CHPs are increasingly providing data for regulatory submissions of various medical devices, the validity, anatomical accuracy, and availability to cover the entire patient population is of utmost importance. The article is organized into two main sections: the first section reviews the different modeling techniques used to create CHPs, whereas the second section discusses various applications of CHPs in biomedical engineering. Each topic gives an overview, a brief history, recent developments, and an outlook into the future.
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Publication type Article: Journal article
Document type Review
Keywords Human Anatomy ; Computational Modeling ; Phantoms
Language english
Publication Year 2019
Prepublished in Year 2018
HGF-reported in Year 2018
ISSN (print) / ISBN 2469-7311
e-ISSN 2469-7311
Journal IEEE transactions on radiation and plasma medical sciences
Quellenangaben Volume: 3, Issue: 1, Pages: 1-23 Article Number: , Supplement: ,
Publisher Institute of Electrical and Electronics Engineers (IEEE)
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Medicine (IRM)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Radiation Sciences
PSP Element(s) G-501391-001
DOI 10.1109/TRPMS.2018.2883437
PubMed ID 30740582
Erfassungsdatum 2019-02-04
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