PuSH - Publication Server of Helmholtz Zentrum München

Kleinert, M. ; Bojsen-Møller, K.N.* ; Jørgensen, N.B.* ; Svane, M.S.* ; Martinussen, C.* ; Kiens, B.* ; Wojtaszewski, J.F.P.* ; Madsbad, S.* ; Richter, E.A.* ; Clemmensen, C.*

Effect of bariatric surgery on plasma GDF15 in humans.

Am. J. Physiol. Endocrinol. Metab. 316, E615-E621 (2019)
Publ. Version/Full Text DOI PMC
Free by publisher
Open Access Green as soon as Postprint is submitted to ZB.
Bariatric surgery results in marked body weight loss and improves type 2 diabetes in most patients with obesity. The growth differentiation factor 15 (GDF15) has recently emerged as a novel satiety factor. To begin to understand whether GDF15 is involved in mediating the effects of bariatric surgery on body weight and glycemia in humans, we measured plasma GDF15 in patients with obesity ( n = 25) and in patients with obesity and diabetes ( n = 22) before and after Roux-en-Y gastric bypass (RYGB) surgery. GDF15 was increased 1 wk after RYGB compared with before surgery (689 ± 45 vs. 487 ± 28 pg/ml, P < 0.001) and GDF15 remained elevated at 3 mo (554 ± 37 pg/ml, P < 0.05), at 1 yr (566 ± 37 pg/ml, P < 0.05), and at 2.5-4 yr (630 ± 50 pg/ml, P < 0.001) after RYGB surgery. Both age and insulin sensitivity correlated with GDF15 before the surgery ( r = 0.46, P < 0.0001 and r = 0.34, P < 0.001, respectively). These correlations disappeared at 2.5-4 yr following the surgery. Conversely, weight loss magnitude correlated with GDF15, measured 2.5-4 yr postsurgery ( r = 0.21, P < 0.0055). In summary, circulating GDF15 increases and correlates with body weight loss following RYGB surgery.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Bariatric Surgery ; Diabetes ; Gdf15 ; Obesity ; Roux-en-y Gastric Bypass; Macrophage Inhibitory Cytokine-1; Insulin-secretion; Weight-loss; Receptor; Biomarker
ISSN (print) / ISBN 0193-1849
e-ISSN 1522-1555
Journal American Journal of Physiology - Endocrinology and Metabolism
Quellenangaben Volume: 316, Issue: 4, Pages: E615-E621 Article Number: , Supplement: ,
Publisher American Physiological Society
Publishing Place 9650 Rockville Pike, Bethesda, Md 20814 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)