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Open Access Green as soon as Postprint is submitted to ZB.
Membrane insertion and intercellular transfer of glycosylphosphatidylinositol-anchored proteins: potential therapeutic applications.
Arch. Physiol. Biochem. 126, 139-156 (2020)
Anchorage of a subset of cell surface proteins in eukaryotic cells is mediated by a glycosylphosphatidylinositol (GPI) moiety covalently attached to the carboxy-terminus of the protein moiety. Experimental evidence for the potential of GPI-anchored proteins (GPI-AP) of being released from cells into the extracellular environment has been accumulating, which involves either the loss or retention of the GPI anchor. Release of GPI-AP from donor cells may occur spontaneously or in response to endogenous or environmental signals. The experimental evidence for direct insertion of exogenous GPI-AP equipped with the complete anchor structure into the outer plasma membrane bilayer leaflets of acceptor cells is reviewed as well as the potential underlying molecular mechanisms. Furthermore, promiscuous transfer of certain GPI-AP between plasma membranes of different cells in vivo under certain (patho)physiological conditions has been reported. Engineering of target cell surfaces using chimeric GPI-AP with complete GPI anchor may be useful for therapeutic applications.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cellular Painting ; Cell Surface Engineering ; Gpi ; Glycosylphosphatidylinositol ; Glycosylphosphatidylinositol-anchored Proteins ; Intercellular Transfer Of Membrane Proteins ; Protein Transduction; Decay-accelerating Factor; Paroxysmal-nocturnal Hemoglobinuria; Variant Surface Glycoprotein; Complement Regulatory Proteins; Small Rat Adipocytes; Alkaline-phosphatase; Lipid Droplets; Phosphatidylinositol Anchor; Saccharomyces-cerevisiae; Induced Translocation
Language
english
Publication Year
2020
Prepublished in Year
2018
HGF-reported in Year
2018
ISSN (print) / ISBN
1381-3455
e-ISSN
1744-4160
Quellenangaben
Volume: 126,
Issue: 2,
Pages: 139-156
Publisher
Informa Healthcare
Publishing Place
Abingdon
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)
POF-Topic(s)
30201 - Metabolic Health
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-502200-001
WOS ID
WOS:000511106400006
Scopus ID
85078958352
PubMed ID
30445857
Erfassungsdatum
2019-02-11