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Arnaldi, D.* ; Meles, S.K.* ; Giuliani, A.* ; Morbelli, S.* ; Renken, R.J.* ; Janzen, A.* ; Mayer, G.* ; Jonsson, C.* ; Oertel, W.H. ; Nobili, F.* ; Leenders, K.L.* ; Pagani, M.* ; REMPET Study Group*

Brain glucose metabolism heterogeneity in idiopathic REM sleep behavior disorder and in parkinson's disease.

J. Parkinsons Dis. 9, 229-239 (2019)
Publ. Version/Full Text DOI PMC
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Background/Objective: Idiopathic REM sleep behavior disorder (iRBD) often precedes Parkinson's disease (PD) and other alpha-synucleinopathies. The aim of the study is to investigate brain glucose metabolism of patients with RBD and PD by means of a multidimensional scaling approach, using F-18-FDG-PET as a biomarker of synaptic function.Methods: Thirty-six iRBD patients (64.1 +/- 6.5 y, 32 M), 72 PD patients, and 79 controls (65.6 +/- 9.4 y, 53 M) underwent brain F-18-FDG-PET. PD patients were divided according to the absence (PD, 32 subjects; 68.4 +/- 8.5 y, 15 M) or presence (PDRBD, 40 subjects; 71.8 +/- 6.6 y, 29 M) of RBD. F-18-FDG-PET scans were used to independently discriminate subjects belonging to four categories: controls (RBD no, PD no), iRBD (RBD yes, PD no), PD (RBD no, PD yes) and PDRBD (RBD yes, PD yes).Results: The discriminant analysis was moderately accurate in identifying the correct category. This is because the model mostly confounds iRBD and PD, thus the intermediate classes. Indeed, iRBD, PD and PDRBD were progressively located at increasing distance from controls and are ordered along a single dimension (principal coordinate analysis) indicating the presence of a single flux of variation encompassing both RBD and PD conditions.Conclusion: Data-driven approach to brain F-18-FDG-PET showed only moderate discrimination between iRBD and PD patients, highlighting brain glucose metabolism heterogeneity among such patients. iRBD should be considered as a marker of an ongoing condition that may be picked-up in different stages across patients and thus express different brain imaging features and likely different clinical trajectories.
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Publication type Article: Journal article
Document type Scientific Article
Keywords 18 F-fdg-pet ; Parkinson's Disease ; Rem Sleep Behavior Disorder ; Synucleinopathy; Mild Cognitive Impairment; Network Activity; Diagnostic-criteria; Fdg-pet; Neurodegeneration; Features; Mri; Rbd
Language
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 1877-7171
e-ISSN 1877-718X
Journal Journal of Parkinson's disease
Quellenangaben Volume: 9, Issue: 1, Pages: 229-239 Article Number: , Supplement: ,
Publisher IOS Press
Publishing Place Amsterdam [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Neurogenomics (ING)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-503200-001
DOI 10.3233/JPD-181468
WOS ID WOS:000457741900020
Scopus ID 85061206299
PubMed ID 30741687
Erfassungsdatum 2019-03-08
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