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Königs, S.K.* ; Pallasch, C.P.* ; Lindner, L.H. ; Schwamb, J.* ; Schulz, A.* ; Brinker, R.* ; Claasen, J.* ; Veldurthy, A.* ; Eibl, H.* ; Hallek, M.* ; Wendtner, C.M.*

Erufosine, a novel alkylphosphocholine, induces apoptosis in CLL through a caspase-dependent pathway.

Leuk. Res. 34, 1064-1069 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The alkylphosphocholine (APC) erufosine is a synthetic phospholipid analogue with antineoplastic activity. APC are known to interact with lipid metabolism and modulate cellular signaling pathways, particularly the phosphorylation of Akt. Here, in primary CLL cells induction of apoptosis was detected with an IC50 of 22muM whereas healthy donor PBMC were less sensitive towards erufosine. Treatment with erufosine caused dose-dependent cleavage of PARP, co-incubation with caspase inhibitor z-VAD almost completely abrogated the cytotoxic effect of erufosine indicating a caspase-dependent mechanism of erufosine. Erufosine was shown to induce apoptosis in primary CLL cells and merits further investigation regarding therapeutic options in CLL.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Erufosine; CLL; Apoptosis; Alkylphospholipid
Language english
Publication Year 2010
HGF-reported in Year 2010
ISSN (print) / ISBN 0145-2126
e-ISSN 1873-5835
Journal Leukemia Research
Quellenangaben Volume: 34, Issue: 8, Pages: 1064-1069 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) CCG Tumor Therapy with Hyperthermia (IMI-KTH)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-521100-001
PubMed ID 20092894
DOI 10.1016/j.leukres.2009.12.003
Scopus ID 77953613405
Erfassungsdatum 2010-12-31
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