PuSH - Publication Server of Helmholtz Zentrum München

Lane, J.M.* ; Jones, S.E.* ; Dashti, H.S.* ; Wood, A.R.* ; Aragam, K.G.* ; van Hees, V.T.* ; Strand, L.B.* ; Winsvold, B.S.* ; Wang, H.* ; Bowden, J.* ; Song, Y.* ; Patel, K.* ; Anderson, S.G.* ; Beaumont, R.N.* ; Bechtold, D.A.* ; Cade, B.E.* ; Haas, M.* ; Kathiresan, S.* ; Little, M.A.* ; Luik, A.I.* ; Loudon, A.S.* ; Purcell, S.* ; Richmond, R.C.* ; Scheer, F.A.J.L.* ; Schormair, B. ; Tyrrell, J.* ; Winkelman, J.W.* ; Winkelmann, J. ; Hveem, K.* ; Zhao, C. ; Nielsen, J.B.* ; Willer, C.J.* ; Redline, S.* ; Spiegelhalder, K.* ; Kyle, S.D.* ; Ray, D.W.* ; Zwart, J.A.* ; Brumpton, B.M.* ; Frayling, T.M.* ; Lawlor, D.A.* ; Rutter, M.K.* ; Weedon, M.N.* ; Saxena, R.*

Biological and clinical insights from genetics of insomnia symptoms.

Nat. Genet. 51, 387-393 (2019)
Postprint DOI PMC
Open Access Green
Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we identified 57 loci for self-reported insomnia symptoms in the UK Biobank (n = 453,379) and confirmed their effects on self-reported insomnia symptoms in the HUNT Study (n = 14,923 cases and 47,610 controls), physician-diagnosed insomnia in the Partners Biobank (n = 2,217 cases and 14,240 controls), and accelerometer-derived measures of sleep efficiency and sleep duration in the UK Biobank (n = 83,726). Our results suggest enrichment of genes involved in ubiquitin-mediated proteolysis and of genes expressed in multiple brain regions, skeletal muscle, and adrenal glands. Evidence of shared genetic factors was found between frequent insomnia symptoms and restless legs syndrome, aging, and cardiometabolic, behavioral, psychiatric, and reproductive traits. Evidence was found for a possible causal link between insomnia symptoms and coronary artery disease, depressive symptoms, and subjective well-being.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Genome-wide Association; Ld Score Regression; Mendelian Randomization; Pharmacological-treatment; Practice Guideline; Sleep; Variants; Risk; Identification; Heritability
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 51, Issue: 3, Pages: 387-393 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Neurogenomics (ING)