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Olefir, I. ; Ghazaryan, A. ; Yang, H. ; Malekzadeh Najafabadi, J. ; Glasl, S. ; Symvoulidis, P. ; O'Leary, V.B.* ; Sergiadis, G.* ; Ntziachristos, V. ; Ovsepian, S.V.

Spatial and spectral mapping and decomposition of neural dynamics and organization of the mouse brain with multispectral optoacoustic tomography.

Cell Rep. 26, 2833-2846.e3 (2019)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
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In traditional optical imaging, limited light penetration constrains high-resolution interrogation to tissue surfaces. Optoacoustic imaging combines the superb contrast of optical imaging with deep penetration of ultrasound, enabling a range of new applications. We used multispectral optoacoustic tomography (MSOT) for functional and structural neuroimaging in mice at resolution, depth, and specificity unattainable by other neuroimaging modalities. Based on multispectral readouts, we computed hemoglobin gradient and oxygen saturation changes related to processing of somatosensory signals in different structures along the entire subcortical-cortical axis. Using temporal correlation analysis and seed-based maps, we reveal the connectivity between cortical, thalamic, and sub-thalamic formations. With the same modality, high-resolution structural tomography of intact mouse brain was achieved based on endogenous contrasts, demonstrating near-perfect matches with anatomical features revealed by histology. These results extend the limits of noninvasive observations beyond the reach of standard high-resolution neuroimaging, verifying the suitability of MSOT for small-animal studies.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Hemodynamic Response ; Label-free Interrogation ; Near-infrared Neuroimaging ; Photoacoustic Imaging ; Temporal Coherence ; Whole-brain Tomography; Diffuse Optical Tomography; In-vivo; Photoacoustic Tomography; Whisker Maps; Blood-flow; Rat-brain; Barrel; Voltage; Cortex; Resolution
Language english
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Journal Cell Reports
Quellenangaben Volume: 26, Issue: 10, Pages: 2833-2846.e3 Article Number: , Supplement: ,
Publisher Cell Press
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505500-001
DOI 10.1016/j.celrep.2019.02.020
WOS ID WOS:000460280800025
Scopus ID 85062088671
PubMed ID 30840901
Erfassungsdatum 2019-03-21
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