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Gujrati, V. ; Prakash, J. ; Malekzadeh Najafabadi, J. ; Stiel, A.-C. ; Klemm, U. ; Mettenleiter, G. ; Aichler, M. ; Walch, A.K. ; Ntziachristos, V.

Bioengineered bacterial vesicles as biological nano-heaters for optoacoustic imaging.

Nat. Commun. 10:1114 (2019)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
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Advances in genetic engineering have enabled the use of bacterial outer membrane vesicles (OMVs) to deliver vaccines, drugs and immunotherapy agents, as a strategy to circumvent biocompatibility and large-scale production issues associated with synthetic nanomaterials. We investigate bioengineered OMVs for contrast enhancement in optoacoustic (photoacoustic) imaging. We produce OMVs encapsulating biopolymer-melanin (OMVMel) using a bacterial strain expressing a tyrosinase transgene. Our results show that upon near-infrared light irradiation, OMVMel generates strong optoacoustic signals appropriate for imaging applications. In addition, we show that OMVMel builds up intense heat from the absorbed laser energy and mediates photothermal effects both in vitro and in vivo. Using multispectral optoacoustic tomography, we noninvasively monitor the spatio-temporal, tumour-associated OMVMel distribution in vivo. This work points to the use of bioengineered vesicles as potent alternatives to synthetic particles more commonly employed for optoacoustic imaging, with the potential to enable both image enhancement and photothermal applications.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Outer-membrane Vesicles; Arrhenius Relationships; Melanin Nanoparticle; Tomography Msot; Cell; Delivery; Molecule; Ablation; Platform; Therapy
Language english
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 10, Issue: 1, Pages: , Article Number: 1114 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
Research Unit Analytical Pathology (AAP)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505500-001
G-505591-004
G-500390-001
DOI 10.1038/s41467-019-09034-y
WOS ID WOS:000460510000011
Scopus ID 85062587044
PubMed ID 30846699
Erfassungsdatum 2019-03-25
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