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Open Access Green as soon as Postprint is submitted to ZB.
P120ctn-mediated organ patterning precedes and determines pancreatic progenitor fate.
Dev. Cell 49, 31-47.e9 (2019)
Publ. Version/Full Text
Research data
DOI
PMC
The mechanism of how organ shape emerges and specifies cell fate is not understood. Pancreatic duct and endocrine lineages arise in a spatially distinct domain from the acinar lineage. Whether these lineages are pre-determined or settle once these niches have been established remains unknown. Here, we reconcile these two apparently opposing models, demonstrating that pancreatic progenitors re-localize to establish the niche that will determine their ultimate fate. We identify a p120ctn-regulated mechanism for coordination of organ architecture and cellular fate mediated by differential E-cadherin based cell sorting. Reduced p120ctn expression is necessary and sufficient to re-localize a subset of progenitors to the peripheral tip domain, where they acquire an acinar fate. The same mechanism is used re-iteratively during endocrine specification, where it balances the choice between the alpha and beta cell fates. In conclusion, organ patterning is regulated by p120ctn-mediated cellular positioning, which precedes and determines pancreatic progenitor fate.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Beta Cell ; Cell Segregation ; Ctnnd1 ; Development ; Differentiation ; Niche ; P120ctn ; Pancreas ; Patterning ; Progenitor; P120 Catenin; E-cadherin; Intercellular-adhesion; Acinar Development; Cell; Organogenesis; Dynamics; Lineage; Tubulogenesis; Expression
ISSN (print) / ISBN
1534-5807
e-ISSN
1878-1551
Journal
Developmental Cell
Quellenangaben
Volume: 49,
Issue: 1,
Pages: 31-47.e9
Publisher
Elsevier
Publishing Place
50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Transl. Stem Cell Research (ITS)