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Energy metabolism in cachexia.
EMBO Rep. 20:e47258 (2019)
Cachexia is a wasting disorder that accompanies many chronic diseases including cancer and results from an imbalance of energy requirements and energy uptake. In cancer cachexia, tumor-secreted factors and/or tumor-host interactions cause this imbalance, leading to loss of adipose tissue and skeletal and cardiac muscle, which weakens the body. In this review, we discuss how energy enters the body and is utilized by the different organs, including the gut, liver, adipose tissue, and muscle, and how these organs contribute to the energy wasting observed in cachexia. We also discuss futile cycles both between the organs and within the cells, which are often used to fine-tune energy supply under physiologic conditions. Ultimately, understanding the complex interplay of pathologic energy-wasting circuits in cachexia can bring us closer to identifying effective treatment strategies for this devastating wasting disease.
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Times Cited
Times Cited
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8.383
1.282
35
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Publication type
Article: Journal article
Document type
Review
Keywords
Adipose Tissue ; Cachexia ; Inflammation ; Liver ; Skeletal Muscle; Brown-adipose-tissue; Acute-phase Response; Skeletal-muscle; Cancer Cachexia; Cachectic Patients; Lipid-metabolism; Weight-loss; Insulin Sensitivity; Pancreatic-cancer; Elderly-patients
Language
english
Publication Year
2019
HGF-reported in Year
2019
ISSN (print) / ISBN
1469-221X
e-ISSN
1469-3178
Journal
EMBO Reports
Quellenangaben
Volume: 20,
Issue: 3,
Article Number: e47258
Publisher
EMBO Press
Publishing Place
111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)
POF-Topic(s)
90000 - German Center for Diabetes Research
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-501900-251
G-501900-254
G-501900-253
G-501900-254
G-501900-253
WOS ID
WOS:000463235300020
Scopus ID
85063081644
Erfassungsdatum
2019-03-26