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Dembek, C.J. ; Kutscher, S. ; Heltai, S.* ; Allgayer, S. ; Biswas, P.* ; Ghezzi, S.* ; Vicenzi, E.* ; Hoffmann, D.* ; Reitmeir, P. ; Tambussi, G.* ; Bogner, J.R.* ; Lusso, P.* ; Stellbrink, H.-J.* ; Santagostino, E.* ; Vollbrecht, T.* ; Goebel, F.D.* ; Protzer, U. ; Draenert, R.* ; Tinelli, M.* ; Poli, G.* ; Erfle, V. ; Malnati, M.* ; Cosma, A.

Nef-specific CD45RA+ CD8+ T cells secreting MIP-1β but not IFN-γ are associated with nonprogressive HIV-1 infection.

Aids Res. Ther. 7, 20 (2010)
Publ. Version/Full Text Volltext DOI PMC
Open Access Gold
BACKGROUND: Long-term survival of HIV-1 infected individuals is usually achieved by continuous administration of combination antiretroviral therapy (ART). An exception to this scenario is represented by HIV-1 infected nonprogressors (NP) which maintain relatively high circulating CD4+ T cells without clinical symptoms for several years in the absence of ART. Several lines of evidence indicate an important role of the T-cell response in the modulation of HIV-1 infection during the acute and chronic phase of the disease. RESULTS: We analyzed the functional and the differentiation phenotype of Nef- and Tat-specific CD8+ T cells in a cohort of HIV-1 infected NP in comparison to progressors, ART-treated seropositive individuals and individuals undergoing a single cycle of ART interruption. We observed that a distinctive feature of NP is the presence of Nef-specific CD45RA+ CD8+ T cells secreting MIP-1beta but not IFN-gamma. This population was present in 7 out of 11 NP. CD45RA+ IFN-gammaneg MIP-1beta+ CD8+ T cells were not detected in HIV-1 infected individuals under ART or withdrawing from ART and experiencing a rebounding viral replication. In addition, we detected Nef-specific CD45RA+ IFN-gammaneg MIP-1beta+ CD8+ T cells in only 1 out of 10 HIV-1 infected individuals with untreated progressive disease. CONCLUSION: The novel antigen-specific CD45RA+ IFN-gammaneg MIP-1beta+ CD8+ T cell population represents a new candidate marker of long-term natural control of HIV-1 disease progression and a relevant functional T-cell subset in the evaluation of the immune responses induced by candidate HIV-1 vaccines.
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Publication type Article: Journal article
Document type Scientific Article
e-ISSN 1742-6405
Journal AIDS Research and Therapy
Quellenangaben Volume: 7, Issue: , Pages: 20 Article Number: , Supplement: ,
Publisher Springer
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute for Metabolism and Immunology (IMI)
Institute of Virology (VIRO)
CCG Immune Monitoring (Platform) (IMI-KIM)
Institute of Health Economics and Health Care Management (IGM)