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Cui, B.* ; Eyers, P.A.* ; Dobens, L.L.* ; Tan, N.S.* ; Mace, P.D.* ; Link, W.A.* ; Kiss-Toth, E.* ; Keeshan, K.* ; Nakamura, T.* ; Pear, W.S.* ; Feseha, Y.* ; Johnston, J.* ; Carracedo, A.* ; Scheideler, M. ; llyas, Z.* ; Bauer, R.C.* ; Erusalimsky, J.D.* ; Grzesik, D.* ; Salamanca-Viloria, J.* ; Lv, X.* ; Jin, Y.* ; Li, K.* ; Velasco, G.* ; Shang, S.* ; Lizcano, J.M.* ; Zhang, X.* ; Zhou, J.* ; Yu, J.* ; Hua, F.* ; Wang, F.* ; Liu, S.* ; Hu, Z.*

Highlights of the 2nd International Symposium on Tribbles and Diseases: Tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer.

Acta Pharm. Sin. B 9, 443-454 (2019)
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The Tribbles (TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2nd International Symposium on Tribbles and Diseases held on May 7-9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases.
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Publication type Article: Journal article
Document type Review
Keywords Tribbles ; Immunology ; Metabolism ; Cell Biology ; Kinase Inhibitor ; Tumorigenesis ; Metastasis ; Trib1 ; Trib2 ; Trib3 ; Pseudokinase ; Inflammation ; Atomic Structure ; Protein Quality Control ; Ubiqutin; Angiopoietin-like 4; Regulates Hepatic Lipogenesis; Trib1; Anagrelide; Expression; Multiple; Gene; Differentiation; Identification; Inhibition
Language english
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 2211-3843
e-ISSN 2211-3835
Journal Acta pharmaceutica Sinica
Quellenangaben Volume: 9, Issue: 2, Pages: 443-454 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-252
DOI 10.1016/j.apsb.2018.12.007
WOS ID WOS:000461052500018
Erfassungsdatum 2019-04-01
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