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Reulen, H.J.* ; Suero Molina, E.* ; Zeidler, R. ; Gildehaus, F.J.* ; Böning, G.* ; Gosewisch, A.* ; Stummer, W.*

Intracavitary radioimmunotherapy of high-grade gliomas: Present status and future developments.

Acta Neurochir. 161, 1109-1124 (2019)
Postprint DOI PMC
Open Access Green
There is a distinct need for new and second-line therapies to delay or prevent local tumor regrowth after current standard of care therapy. Intracavitary radioimmunotherapy, in combination with radiotherapy, is discussed in the present review as a therapeutic strategy of high potential. We performed a systematic literature search following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA). The available body of literature on intracavitary radioimmunotherapy (iRIT) in glioblastoma and anaplastic astrocytomas is presented. Several past and current phase I and II clinical trials, using mostly an anti-tenascin monoclonal antibody labeled with I-131, have shown median overall survival of 19–25 months in glioblastoma, while adverse events remain low. Tenascin, followed by EGFR and variants, or smaller peptides have been used as targets, and most clinical studies were performed with I-131 or Y-90 as radionuclides while only recently Re-188, I-125, and Bi-213 were applied. The pharmacokinetics of iRIT, as well as the challenges encountered with this therapy, is comprehensively discussed. This promising approach deserves further exploration in future studies by incorporating several innovative modifications.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Intracavitary Radioimmunotherapy ; Locoregional Therapy ; Glioblastomas ; High-grade Gliomas ; Malignant Gliomas
ISSN (print) / ISBN 0001-6268
e-ISSN 0942-0940
Journal Acta neurochirurgica
Quellenangaben Volume: 161, Issue: 6, Pages: 1109-1124 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Wien [u.a.]
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit Gene Vector (AGV)