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Open Access Green as soon as Postprint is submitted to ZB.
Genetik des Typ-2-Diabetes.
Genetic background of type 2 diabetes.
Diabetologie 15, 267-277 (2019)
Type 2 diabetes mellitus is amultifactorial disease with an obvious polygenetic component. Using family-based linkage analysis, candidate gene-based genotype-phenotype association analysis, and the by far most successful method of hypothesis-free genome-wide association analysis, a total of 403 independent, mostly common gene variants in 243 gene loci significantly associated with type 2 diabetes risk have been hitherto identified. The gene variant with the most robust effect on type 2 diabetes risk is located in the TCF7L2 (transcription factor 7-like 2) gene locus and reduces incretin sensitivity of pancreatic -cells and limits the therapeutic response to drugs that make use of the incretin axis. Such pathomechanistic insights are currently only available for very few of the type 2 diabetes genes. Pathomechanistic investigations are hampered by gene-gene, gene-lifestyle, and gene-environment interactions. This is one of the main reasons why the impact of the risk alleles on type 2 diabetes prediction is still very limited.
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Publication type
Article: Journal article
Document type
Review
Keywords
Diabetes Mellitus ; Non-insulin Dependent ; Glucose Metabolism Disorders ; Genetic Loci ; Inheritance Patterns ; Polymorphism ; Genetic; Insulin-secretion; Weight-loss; Tcf7l2; Variants; Association; Concordance; Mellitus; Obesity
ISSN (print) / ISBN
2731-7447
e-ISSN
2731-7455
Journal
Diabetologie, Die
Quellenangaben
Volume: 15,
Issue: 3,
Pages: 267-277
Publisher
Springer
Publishing Place
Tiergartenstrasse 17, D-69121 Heidelberg, Germany
Non-patent literature
Publications
Reviewing status
Peer reviewed