PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Mishra, K. ; Fuenzalida Werner, J.P. ; Ntziachristos, V. ; Stiel, A.-C.

Photocontrollable proteins for optoacoustic imaging.

Anal. Chem. 91, 5470-5477 (2019)
Postprint DOI PMC
Open Access Green
Photocontrollable proteins revolutionized life-science imaging due to their contribution to subdiffraction-resolution optical microscopy. They might have yet another lasting impact on photo- or optoacoustic imaging (OA). OA combines optical contrast with ultrasound detection enabling high-resolution real-time in vivo imaging well-beyond the typical penetration depth of optical methods. While OA already showed numerous applications relying on endogenous contrast from blood hemoglobin or lipids, its application in the life-science was limited by a lack of labels overcoming the strong signal from the aforementioned endogenous absorbers. Here, a number of recent studies showed that photocontrollable proteins provide the means to overcome this barrier eventually enabling OA to image small cell numbers in a complete organism in vivo. In this Feature article, we introduce the key photocontrollable proteins, explain the basic concepts, and highlight achievements that have been already made.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
6.350
1.486
2
9
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Review
Keywords Lock-in Detection; Fluorescent Proteins; Photoacoustic Tomography; Natural Photoreceptors; Performance; Chromophore; Microscopy
Language english
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 0003-2700
e-ISSN 1520-6882
Journal Analytical Chemistry
Quellenangaben Volume: 91, Issue: 9, Pages: 5470-5477 Article Number: , Supplement: ,
Publisher American Chemical Society (ACS)
Publishing Place 1155 16th St, Nw, Washington, Dc 20036 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505591-004
G-505500-001
DOI 10.1021/acs.analchem.9b01048
WOS ID WOS:000467642100002
Scopus ID 85064805117
PubMed ID 30933491
Erfassungsdatum 2019-04-24
[➜Report correction]