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Karlas, A. ; Fasoula, N.-A. ; Paul-Yuan, K. ; Reber, J. ; Kallmayer, M.* ; Bozhko, D. ; Seeger, M. ; Eckstein, H.H.* ; Wildgruber, M.* ; Ntziachristos, V.

Cardiovascular optoacoustics: From mice to men - A review.

Photoacoustics 14, 19-30 (2019)
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Imaging has become an indispensable tool in the research and clinical management of cardiovascular disease (CVD). An array of imaging technologies is considered for CVD diagnostics and therapeutic assessment, ranging from ultrasonography, X-ray computed tomography and magnetic resonance imaging to nuclear and optical imaging methods. Each method has different operational characteristics and assesses different aspects of CVD pathophysiology; nevertheless, more information is desirable for achieving a comprehensive view of the disease. Optoacoustic (photoacoustic) imaging is an emerging modality promising to offer novel information on CVD parameters by allowing high-resolution imaging of optical contrast several centimeters deep inside tissue. Implemented with illumination at several wavelengths, multi-spectral optoacoustic tomography (MSOT) in particular, is sensitive to oxygenated and deoxygenated hemoglobin, water and lipids allowing imaging of the vasculature, tissue oxygen saturation and metabolic or inflammatory parameters. Progress with fast-tuning lasers, parallel detection and advanced image reconstruction and data-processing algorithms have recently transformed optoacoustics from a laboratory tool to a promising modality for small animal and clinical imaging. We review progress with optoacoustic CVD imaging, highlight the research and diagnostic potential and current applications and discuss the advantages, limitations and possibilities for integration into clinical routine.
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Publication type Article: Journal article
Document type Review
Keywords Non-invasive Imaging ; Cardiovascular Disease ; Photoacoustics ; Msot ; Clinical Translation; Pulse-wave Velocity; Atherosclerotic Plaque; Indocyanine Green; Tomography Msot; Photoacoustic Tomography; Natural-history; Skeletal-muscle; Ultrasound; Coronary; Angiogenesis
Language english
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 2213-5979
Journal Photoacoustics
Quellenangaben Volume: 14, Issue: , Pages: 19-30 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Hackerbrucke 6, 80335 Munich, Germany
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505500-001
DOI 10.1016/j.pacs.2019.03.001
WOS ID WOS:000503215500003
Scopus ID 85064326692
PubMed ID 31024796
Erfassungsdatum 2019-04-26
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