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Tumor cell dormancy-triggered by the niche.
Dev. Cell 49, 311-312 (2019)
Dormant cancer cells often survive treatment and increase the risk for tumor relapse, associated with dismal prognosis. Two recent papers describe mechanisms used by the bone marrow niche to regulate leukemia dormancy. The findings provide a molecular basis for niche-targeting therapies that may enable elimination of dormant tumor cells.
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Publication type
Article: Journal article
Document type
Letter to the Editor
Keywords
Self-renewal; Leukemia
Language
english
Publication Year
2019
HGF-reported in Year
2019
ISSN (print) / ISBN
1534-5807
e-ISSN
1878-1551
Journal
Developmental Cell
Quellenangaben
Volume: 49,
Issue: 3,
Pages: 311-312
Publisher
Elsevier
Publishing Place
50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status
Peer reviewed
Institute(s)
Research Unit Apoptosis in Hematopoietic Stem Cells (AHS)
POF-Topic(s)
30204 - Cell Programming and Repair
Research field(s)
Stem Cell and Neuroscience
PSP Element(s)
G-506600-001
WOS ID
WOS:000466934100006
Scopus ID
85064699658
PubMed ID
31063749
Erfassungsdatum
2019-05-10