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Förster, K. ; Ertl-Wagner, B. ; Ehrhardt, H.* ; Busen, H. ; Sass, S. ; Pomschar, A.* ; Naehrlich, L.* ; Schulze, A.* ; Flemmer, A.W.* ; Hübener, C.* ; Eickelberg, O. ; Theis, F.J. ; Dietrich, O.* ; Hilgendorff, A.

Altered relaxation times in MRI indicate bronchopulmonary dysplasia.

Thorax 75, 184-187 (2020)
Postprint DOI PMC
Open Access Green
We developed a MRI protocol using transverse (T2) and longitudinal (T1) mapping sequences to characterise lung structural changes in preterm infants with bronchopulmonary dysplasia (BPD). We prospectively enrolled 61 infants to perform 3-Tesla MRI of the lung in quiet sleep. Statistical analysis was performed using logistic Group Lasso regression and logistic regression. Increased lung T2 relaxation time and decreased lung T1 relaxation time indicated BPD yielding an area under the curve (AUC) of 0.80. Results were confirmed in an independent study cohort (AUC 0.75) and mirrored by lung function testing, indicating the high potential for MRI in future BPD diagnostics.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Paediatric Lung Disaese; Magnetic-resonance; Inflammation; Injury
ISSN (print) / ISBN 0040-6376
e-ISSN 1468-3296
Journal Thorax
Quellenangaben Volume: 75, Issue: 2, Pages: 184-187 Article Number: , Supplement: ,
Publisher BMJ Publishing Group
Publishing Place British Med Assoc House, Tavistock Square, London Wc1h 9jr, England
Non-patent literature Publications
Reviewing status Peer reviewed