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Thyssen, J.P.* ; de Bruin-Weller, M.S.* ; Paller, A.S.* ; Leshem, Y.A.* ; Vestergaard, C.* ; Deleuran, M.* ; Drucker, A.M.* ; Foelster-Holst, R.* ; Traidl-Hoffmann, C. ; Eyerich, K.* ; Taïeb, A.* ; Su, J.C.* ; Bieber, T.* ; Cork, M.J.* ; Eichenfield, L.F.* ; Guttman-Yassky, E.* ; Wollenberg, A.*

Conjunctivitis in atopic dermatitis patients with and without dupilumab therapy - international eczema council survey and opinion.

J. Eur. Acad. Dermatol. Venereol. 33, 1224-1231 (2019)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Background Conjunctivitis is common in patients with atopic dermatitis (AD) in general and a commonly reported adverse event in AD clinical trials with dupilumab. Objective To survey opinions and experience about conjunctivitis occurring in AD, including those during dupilumab treatment in a group of AD experts from the International Eczema Council (IEC). Methods Electronic survey and in-person discussion of management strategies. Results Forty-six (53.5%) IEC members from 19 countries responded to the survey. Consensus was reached for several statements regarding diagnostic workup, referral and treatment. IEC members suggest that patients with AD should (i) routinely be asked about ocular complaints or symptoms, (ii) obtain information about the potential for conjunctivitis before starting dupilumab therapy and (iii) if indicated, be treated with dupilumab despite previous or current conjunctivitis. In cases of new-onset conjunctivitis, there was consensus that dupilumab treatment should be continued when possible, with appropriate referral to an ophthalmologist. Limitations The study relies on expert opinion from dermatologists. Responses from few dermatologists without dupilumab access were not excluded from the survey. Conclusion The IEC recommends that dermatologists address conjunctivitis in patients with AD, especially during treatment with dupilumab.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords 2-phase 3 Trials; European Guidelines; Management; Care; Diagnosis; Placebo; Adults; Keratoconjunctivitis; Disease; Eye
ISSN (print) / ISBN 0926-9959
e-ISSN 1468-3083
Journal Journal of the European Academy of Dermatology and Venereology
Quellenangaben Volume: 33, Issue: 7, Pages: 1224-1231 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Environmental Medicine (IEM)