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Koch, S.* ; Damas, M.* ; Freise, A.* ; Hage, E.* ; Dhingra, A.* ; Rückert, J.* ; Gallo, A.* ; Kremmer, E. ; Tegge, W.* ; Brönstrup, M.* ; Brune, W.* ; Schulz, T.F.*

Kaposi's sarcoma-associated herpesvirus vIRF2 protein utilizes an IFN-dependent pathway to regulate viral early gene expression.

PLoS Pathog. 15:e1007743 (2019)

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Kaposi's sarcoma-associated herpesvirus (KSHV; human herpesvirus 8) belongs to the subfamily of Gammaherpesvirinae and is the etiological agent of Kaposi's sarcoma as well as of two lymphoproliferative diseases: primary effusion lymphoma and multicentric Castleman disease. The KSHV life cycle is divided into a latent and a lytic phase and is highly regulated by viral immunomodulatory proteins which control the host antiviral immune response. Among them is a group of proteins with homology to cellular interferon regulatory factors, the viral interferon regulatory factors 1-4. The KSHV vIRFs are known as inhibitors of cellular interferon signaling and are involved in different oncogenic pathways. Here we characterized the role of the second vIRF protein, vIRF2, during the KSHV life cycle. We found the vIRF2 protein to be expressed in different KSHV positive cells with early lytic kinetics. Importantly, we observed that vIRF2 suppresses the expression of viral early lytic genes in both newly infected and reactivated persistently infected endothelial cells. This vIRF2-dependent regulation of the KSHV life cycle might involve the increased expression of cellular interferon-induced genes such as the IFIT proteins 1, 2 and 3, which antagonize the expression of early KSHV lytic proteins. Our findings suggest a model in which the viral protein vIRF2 allows KSHV to harness an IFN-dependent pathway to regulate KSHV early gene expression.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Pml Oncogenic Domains; Epstein-barr-virus; Lytic Cycle Replication; Human Endothelial-cells; Human Cytomegalovirus; Dna-replication; Nuclear-bodies; Inflammatory Cytokines; Covalent Modification; Primary Infection

ISSN (print) / ISBN 1553-7366

e-ISSN 1553-7374

Journal PLoS Pathogens

Quellenangaben Volume: 15, Issue: 5, Article Number: e1007743

Publisher Public Library of Science (PLoS)

Publishing Place 1160 Battery Street, Ste 100, San Francisco, Ca 94111 Usa

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Molecular Immunology (IMI)