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Extension of the minimal functional unit of the RNA polymerase II CTD from yeast to mammalian cells.
Biol. Lett. 15:20190068 (2019)
The carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) consists of 26 and 52 heptad-repeats in yeast and mammals, respectively. Studies in yeast showed that the strong periodicity of the YSPTSPS heptads is dispensable for cell growth and that di-heptads interspersed by spacers can act as minimal functional units (MFUs) to fulfil all essential CTD functions. Here, we show that the MFU of mammalian cells is significantly larger than in yeast and consists of penta-heptads. We further show that the distance between two MFUs is critical for the functions of mammalian CTD. Our study suggests that the general structure of the CTD remained largely unchanged in yeast and mammals; however, besides the number of heptad-repeats, also the length of the MFU significantly increased in mammals.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Rna Polymerase Ii (pol Ii) ; C-terminal Domain (ctd) ; Heptad-repeats ; Low-complexity Domain ; Minimal Functional Unit (mfu); Carboxyl-terminal Domain; Largest Subunit; Integrator Complex; Phosphorylation; Transcription; Mediator; Repeat; Code
ISSN (print) / ISBN
1744-9561
e-ISSN
1744-957X
Journal
Biology letters
Quellenangaben
Volume: 15,
Issue: 5,
Article Number: 20190068
Publisher
Royal Society of Chemistry (RSC)
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Functional Epigenetics (IFE)