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Meisinger, C. ; Rospleszcz, S. ; Wintermeyer, E.* ; Lorbeer, R.* ; Thorand, B. ; Bamberg, F.* ; Peters, A. ; Schlett, C.L.* ; Linseisen, J.

Isocaloric substitution of dietary carbohydrate intake with fat intake and MRI-determined total volumes of visceral, subcutaneous and hepatic fat content in middle-aged adults.

Nutrients 11:1151 (2019)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The present study investigated the association of carbohydrate intake and isocaloric substitution with different types of fat with visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and hepatic fat content as determined by magnetic resonance imaging (MRI). Data from 283 participants (mean age 56.1 +/- 9.0 years) from the MRI sub study of the KORA FF4 study were included. VAT, SAT and total body fat were quantified by a volume-interpolated VIBE-T1w-Dixon MR sequence. Hepatic fat content was determined as the proton density fat-fraction (PDFF) derived from multiecho-T1w MR sequence. Dietary intake was estimated using information provided by two different instruments, that is, repeated 24-h food lists and a food frequency questionnaire. Replacing total carbohydrates with an isoenergetic amount of total fat was significantly positively associated with VAT and hepatic fat, while there was no significant association with SAT. The multivariable adjusted -coefficient for replacing 5% of total energy (5E%) carbohydrates with total fat was 0.42 L (95% CI: 0.04, 0.79) for VAT. A substitution in total fat intake by 5E% was associated with a significant increase in liver fat content by 23% (p-value 0.004). If reproduced in prospective studies, such findings would strongly argue for limiting dietary fat intake.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Hepatic Fat Content ; Visceral Adipose Tissue ; Body Fat Compartments ; Fat Intake ; Diet ; Mri; Adipose-tissue; Liver Fat; Risk-factors; Cardiovascular-disease; Insulin Sensitivity; Abdominal Obesity; Acid-composition; Consumption; Food; Resistance
ISSN (print) / ISBN 2072-6643
e-ISSN 2072-6643
Journal Nutrients
Quellenangaben Volume: 11, Issue: 5, Pages: , Article Number: 1151 Supplement: ,
Publisher MDPI
Publishing Place Basel
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Independent Research Group Clinical Epidemiology (KEPI)
Institute of Epidemiology II (EPI2)