PuSH - Publication Server of Helmholtz Zentrum München: Genome-lamina interactions are established de novo in the early mouse embryo.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Borsos, M. ; Perricone, S.M.* ; Schauer, T.* ; Pontabry, J. ; de Luca, K.L.* ; de Vries, S.S.* ; Ruiz-Morales, E.R. ; Torres-Padilla, M.E. ; Kind, J.*

Genome-lamina interactions are established de novo in the early mouse embryo.

Nature 569, 729-733 (2019)

Postprint

DOI

PMC

	Open Access Green

Abstract
Metrics
Extra information

In mammals, the emergence of totipotency after fertilization involves extensive rearrangements of the spatial positioning of the genome(1,2). However, the contribution of spatial genome organization to the regulation of developmental programs is unclear(3). Here we generate high-resolution maps of genomic interactions with the nuclear lamina (a filamentous meshwork that lines the inner nuclear membrane) in mouse pre-implantation embryos. We reveal that nuclear organization is not inherited from the maternal germline but is instead established de novo shortly after fertilization. The two parental genomes establish lamina-associated domains (LADs)(4) with different features that converge after the 8-cell stage. We find that the mechanism of LAD establishment is unrelated to DNA replication. Instead, we show that paternal LAD formation in zygotes is prevented by ectopic expression of Kdm5b, which suggests that LAD establishment may be dependent on remodelling of H3K4 methylation. Our data suggest a step-wise assembly model whereby early LAD formation precedes consolidation of topologically associating domains.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

43.070

9.199