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From old to new - Repurposing drugs to target mitochondrial energy metabolism in cancer.
Semin. Cell Dev. Biol. 98, 211-223 (2020)
Although we have entered the era of personalized medicine and tailored therapies, drugs that target a large variety of cancers regardless of individual patient differences would be a major advance nonetheless. This review article summarizes current concepts and therapeutic opportunities in the area of targeting aerobic mitochondrial energy metabolism in cancer. Old drugs previously used for diseases other than cancer, such as antibiotics and antidiabetics, have the potential to inhibit the growth of various tumor entities. Many drugs are reported to influence mitochondrial metabolism. However, here we consider only those drugs which predominantly inhibit oxidative phosphorylation.
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Publication type
Article: Journal article
Document type
Review
Keywords
Aerobic Mitochondrial Energy Metabolism ; Oxidative Phosphorylation Complex ; Antibiotic ; Antidiabetic ; Chemotherapeutic; Induced Oxidative Stress; Chronic Myeloid-leukemia; Cell-cycle Arrest; Complex-i; Lung-cancer; Stem-cells; Inhibits Proliferation; Antibiotic Exposure; Somatic Mutations; Dna Mutations
ISSN (print) / ISBN
1084-9521
e-ISSN
1096-3634
Quellenangaben
Volume: 98,
Pages: 211-223
Publisher
Academic Press
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Human Genetics (IHG)