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Metabolic regulation through the endosomal system.
Traffic 20, 552-570 (2019)
Publ. Version/Full Text
Postprint
DOI
PMC
The endosomal system plays an essential role in cell homeostasis by controlling cellular signaling, nutrient sensing, cell polarity and cell migration. However, its place in the regulation of tissue, organ and whole body physiology is less well understood. Recent studies have revealed an important role for the endosomal system in regulating glucose and lipid homeostasis, with implications for metabolic disorders such as type 2 diabetes, hypercholesterolemia and non-alcoholic fatty liver disease. By taking insights from in vitro studies of endocytosis and exploring their effects on metabolism, we can begin to connect the fields of endosomal transport and metabolic homeostasis. In this review, we explore current understanding of how the endosomal system influences the systemic regulation of glucose and lipid metabolism in mice and humans. We highlight exciting new insights that help translate findings from single cells to a wider physiological level and open up new directions for endosomal research.
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Publication type
Article: Journal article
Document type
Review
Keywords
Diabetes ; Endocytosis ; Fatty Liver Disease ; Glucose And Lipid Metabolism ; Metabolic Signaling ; Nutrient Transport; Receptor-mediated Endocytosis; Induced Glut4 Translocation; Hepatic Glucose-production; Insulin-receptor; Lysosomal Degradation; Caveolin-1-deficient Mice; Signal-transduction; Hormonal-regulation; Gene-transcription; Down-regulation
ISSN (print) / ISBN
1398-9219
e-ISSN
1600-0854
Journal
Traffic
Quellenangaben
Volume: 20,
Issue: 8,
Pages: 552-570
Publisher
Wiley
Publishing Place
Oxford
Non-patent literature
Publications
Reviewing status
Peer reviewed