PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Czamara, D.* ; Eraslan, G. ; Page, C.M.* ; Lahti, J.* ; Lahti-Pulkkinen, M.* ; Hämäläinen, E.* ; Kajantie, E.* ; Laivuori, H.* ; Villa, P.M.* ; Reynolds, R.M.* ; Nystad, W.* ; Håberg, S.E.* ; London, S.J.* ; O'Donnell, K.J.* ; Garg, E.* ; Meaney, M.J.* ; Entringer, S.* ; Wadhwa, P.D.* ; Buss, C.* ; Jones, M.J.* ; Lin, D.T.S.* ; MacIsaac, J.L.* ; Kobor, M.S.* ; Koen, N.* ; Zar, H.J.* ; Koenen, K.C.* ; Dalvie, S.* ; Stein, D.J.* ; Kondofersky, I. ; Müller, N.S. ; Theis, F.J. ; Räikkönen, K.* ; Binder, E.B.*

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.

Nat. Commun. 10:2548 (2019)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike's information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
11.878
2.805
40
66
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Childhood Maltreatment; Norwegian Mother; Maternal Smoking; Prenatal Stress; Genome-wide; In-utero; Pregnancy; Risk; Birth; Genotype
Language english
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 10, Issue: 1, Pages: , Article Number: 2548 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-503800-001
DOI 10.1038/s41467-019-10461-0
WOS ID WOS:000470968400008
Scopus ID 85067229888
PubMed ID 31186427
Erfassungsdatum 2019-06-14
[➜Report correction]