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Schilling, D. ; Herold, B.* ; Combs, S.E. ; Schmid, T.E.

Selenium does not affect radiosensitivity of breast cancer cell lines.

Radiat. Environ. Biophys. 58, 433-438 (2019)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Supplementation with the antioxidant selenium is frequently performed in breast cancer patients to protect the normal tissue from radiation-induced side effects. However, concerns exist whether selenium also protects tumor cells from radiation-induced cell kill and thereby reduces the efficacy of radiotherapy. In this work, the effect of selenium administration on the radiosensitivity of breast cancer cells was evaluated in vitro. Physiological relevant selenium concentrations (70 and 140 mu g/l) did not affect DNA double-strand breaks (gamma H2AX foci) after 4-Gy X-ray irradiation. Also apoptosis (caspase 3/7) after irradiation with 10Gy was not influenced by selenium treatment in MDA-MB-231 and MCF7 cells. Most importantly, selenium supplementation did not impair the clonogenic survival of the breast cancer cell lines after irradiation (0, 2, 4, 6, 8Gy). The data suggest that physiological relevant selenium concentrations administered in combination with radiation therapy do not deteriorate the efficacy of radiotherapy in breast cancer patients. However, randomized clinical trials comparing the effectiveness of radiotherapy and the associated side effects in patients with and without selenium supplementation are recommended.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Selenium ; Radiation ; Breast Cancer ; Radiosensitivity ; Antioxidant ; Supplementation; Sodium Selenite; Serum-levels; Lung-cancer; Tumor-cells; Radiation; Supplementation; Prevention; Modulation; Oncology; Oxygen
ISSN (print) / ISBN 0301-634X
e-ISSN 1432-2099
Journal Radiation and Environmental Biophysics
Quellenangaben Volume: 58, Issue: 3, Pages: 433-438 Article Number: , Supplement: ,
Publisher Springer
Publishing Place 233 Spring St, New York, Ny 10013 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Medicine (IRM)