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Kirjavainen, P.V.* ; Karvonen, A.M.* ; Adams, R.I.* ; Täubel, M.* ; Roponen, M.* ; Tuoresmäki, P.* ; Loss, G.* ; Jayaprakash, B.* ; Depner, M. ; Ege, M.J.* ; Renz, H.* ; Pfefferle, P.I.* ; Schaub, B.* ; Lauener, R.* ; Hyvärinen, A.* ; Knight, R.* ; Heederik, D.J.J.* ; von Mutius, E. ; Pekkanen, J.*

Farm-like indoor microbiota in non-farm homes protects children from asthma development.

Nat. Med. 25, 1089-1095 (2019)
Postprint DOI PMC
Open Access Green
Asthma prevalence has increased in epidemic proportions with urbanization, but growing up on traditional farms offers protection even today(1). The asthma-protective effect of farms appears to be associated with rich home dust microbiota(2,3), which could be used to model a health-promoting indoor microbiome. Here we show by modeling differences in house dust microbiota composition between farm and non-farm homes of Finnish birth cohorts(4) that in children who grow up in non-farm homes, asthma risk decreases as the similarity of their home bacterial microbiota composition to that of farm homes increases. The protective microbiota had a low abundance of Streptococcaceae relative to outdoor-associated bacterial taxa. The protective effect was independent of richness and total bacterial load and was associated with reduced proinflammatory cytokine responses against bacterial cell wall components ex vivo. We were able to reproduce these findings in a study among rural German children(2) and showed that children living in German non-farm homes with an indoor microbiota more similar to Finnish farm homes have decreased asthma risk. The indoor dust microbiota composition appears to be a definable, reproducible predictor of asthma risk and a potential modifiable target for asthma prevention.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Early-life; Analytical Performance; Childhood Asthma; Moisture Damage; Bacterial; Exposure; Allergy; Diversity; Endotoxin; Dust
Language english
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 1078-8956
e-ISSN 1546-170X
Journal Nature medicine
Quellenangaben Volume: 25, Issue: 7, Pages: 1089-1095 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Asthma and Allergy Prevention (IAP)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Allergy
PSP Element(s) G-503300-001
DOI 10.1038/s41591-019-0469-4
WOS ID WOS:000474430400022
PubMed ID 31209334
Erfassungsdatum 2019-08-06
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