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Pleurectomy/decortication and hyperthermic intrathoracic chemoperfusion using cisplatin and doxorubicin for malignant pleural mesothelioma.
J. Thorac. Dis. 11, 1963-1972 (2019)
Background: Malignant pleural mesothelioma (MPM) is an aggressive malignancy with few long-term survivors. Despite the dismal prognosis, hyperthermic intrathoracic chemoperfusion (HITHOC) was shown to improve survival in a selective group of patients. We analyzed the influence of HITHOC following pleurectomy and decortication on postoperative morbidity and overall survival for patients suffering from localized mesothelioma. Methods: From 2009 until 2013, 71 patients with localized pleural mesothelioma underwent pleurectomy and decortication followed by HITHOC with cisplatin and doxorubicin. We analyzed postoperative morbidity, age, overall survival and influence of macroscopic resection on survival. Results: Median patient age was 70 years (range, 65-73 years). Patients having the sarcomatoid subtype of mesothelioma showed a poor median survival of 9.2 months. In contrast, patients having the epithelioid subtype had a median survival of 17.9 months. Patients following macroscopic complete resection had a significantly better survival with 28.2 months compared to 13.1 months in patients with incomplete resection of the mesothelioma (P<0.0001). HITHOC was performed in all patients after tumor resection using cisplatin and doxorubicin. Conclusions: Taken together, HITHOC following pleurectomy and decortication is supposed to be a safe therapeutic option for selected patients with localized epithelial pleural mesothelioma.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Pleural Mesothelioma ; Chemoperfusion, Decortication ; Cisplatin ; Hyperthermic Intrathoracic Chemoperfusion (hithoc); Cytoreductive Surgery; Pleurectomy-decortication; Extended Pleurectomy; Chemotherapy; Survival; Management; Diagnosis; Classification; Metaanalysis; Guidelines
Language
english
Publication Year
2019
HGF-reported in Year
2019
ISSN (print) / ISBN
2077-6624
e-ISSN
2072-1439
Journal
Journal of thoracic disease
Quellenangaben
Volume: 11,
Issue: 5,
Pages: 1963-1972
Publisher
Pioneer Bioscience Publ.
Publishing Place
Hong Kong
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Lung Research
PSP Element(s)
G-501600-001
G-501600-003
G-501600-003
WOS ID
WOS:000469979100030
Scopus ID
85067114078
PubMed ID
31285889
Erfassungsdatum
2019-06-24