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Schulte, E.C. ; Kaffe, M.* ; Schormair, B. ; Winkelmann, J.

Iron in restless legs syndrome.

Mov. Disord. Clin. Pract. 1, 161-172 (2014)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
A link between restless legs syndrome (RLS) and iron has been recognized for several decades. Yet, the precise role that iron or other components of iron metabolism play in bringing about RLS is still a matter of debate. During the last few years, many new pieces of evidence from genetics, pathology, imaging, and clinical studies have surfaced. However, the way this evidence fits into the larger picture of RLS as a disease is not always easily understood. To provide a better understanding of the complex interplay between iron metabolism and RLS and highlight areas that need further elucidation, we systematically and critically review the current literature on the role of iron in RLS pathophysiology and treatment with a special emphasis on genetics, neuropathology, cell and animal models, imaging studies, and therapy.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Genetics ; Imaging ; Iron ; Restless Legs Syndrome ; Therapy
ISSN (print) / ISBN 2330-1619
e-ISSN 2330-1619
Journal Movement disorders clinical practice
Quellenangaben Volume: 1, Issue: 3, Pages: 161-172 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Neurogenomics (ING)
Institute of Human Genetics (IHG)