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Wang, H.X.* ; Gires, O.

Tumor-derived extracellular vesicles in breast cancer: From bench to bedside.

Cancer Lett. 460, 54-64 (2019)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Tumor-derived extracellular vesicles (TEVs) released from various tumor cell types comprise endosome-derived exosomes and microvesicles (MVs), which originate from plasma membrane budding. TEVs incorporate a myriad of biomolecules such as proteins, DNAs, metabolites and microRNAs, which can be transferred from cell-to-cell. Besides their role in the disposal of biomolecules, TEVs serve to orchestrate fundamental processes of normal and malignant development, including breast cancer (BC). As such, TEVs are important constituents of the tumor microenvironment (TME) that act as communication shuttles through transduction of encapsulated molecular cargos from a parent to a recipient cell and through direct interaction with target cells. Emerging evidence suggests that TEVs support BC development and disease progression by fostering invasion, angiogenesis, premetastatic niche preparation, escape from immune surveillance, and induction of resistance to treatment. Although there is a long way to go in order to translate the current knowledge into actual clinical applications, TEVs represent promising candidates for diagnostic biomarkers, therapeutic carriers and targets. In the present review, we will summarize the current knowledge on TEVs in BC.
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Publication type Article: Journal article
Document type Review
Keywords Extracellular Vesicles ; Exosomes ; Microvesicles ; Metastatic Breast Cancer ; Liquid Biopsy ; Tumor Microenvironment; Exosome-mediated Transfer; Mesenchymal Stem-cells; Drug-delivery; Membrane Curvature; Messenger-rna; Stromal Cells; In-vitro; Protein; Microvesicles; Proteomics
Language english
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 0304-3835
e-ISSN 0304-3835
Journal Cancer Letters
Quellenangaben Volume: 460, Issue: , Pages: 54-64 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland
Reviewing status Peer reviewed
Institute(s) Translational Metabolic Oncology (IDC-TMO)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Radiation Sciences
PSP Element(s) G-521800-001
DOI 10.1016/j.canlet.2019.06.012
WOS ID WOS:000481564900007
Scopus ID 85067839178
PubMed ID 31233837
Erfassungsdatum 2019-06-27
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