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Potential use of gluconate in cancer therapy.
Front. Oncol. 9:522 (2019)
We have recently discovered that cancer cells take up extracellular citrate through plasma membrane citrate transporter (pmCiC) and advantageously use citrate for their metabolism. Citrate uptake can be blocked with gluconate and this results in decreased tumor growth and altered metabolic characteristics of tumor tissue. Interestingly, gluconate, considered to be physiologically neutral, is incidentally used in medicine as a cation carrier, but not as a therapeutically active substance. In this review we discuss the results of our recent research with available literature and suggest that gluconate may be useful in the treatment of cancer.
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Publication type
Article: Journal article
Document type
Review
Keywords
Cancer Metabolism ; Citrate ; Gluconate ; Metabolic Targeting ; Transporter; Sodium Stibogluconate; Magnesium Infusions; Phase-ii; In-vitro; Disulfiram; Prevention; Antimony; Calcium; Cells; Immunotherapy
ISSN (print) / ISBN
2234-943X
e-ISSN
2234-943X
Journal
Frontiers in Oncology
Quellenangaben
Volume: 9,
Article Number: 522
Publisher
Frontiers
Publishing Place
Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Molekulare Endokrinologie und Metabolismus (MEM)