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Mycielska, M.E.* ; Mohr, M.T.J.* ; Schmidt, K.* ; Drexler, K.* ; Ruemmele, P.* ; Haferkamp, S.* ; Schlitt, H.J.* ; Gaumann, A.* ; Adamski, J. ; Geissler, E.K.*

Potential use of gluconate in cancer therapy.

Front. Oncol. 9:522 (2019)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
We have recently discovered that cancer cells take up extracellular citrate through plasma membrane citrate transporter (pmCiC) and advantageously use citrate for their metabolism. Citrate uptake can be blocked with gluconate and this results in decreased tumor growth and altered metabolic characteristics of tumor tissue. Interestingly, gluconate, considered to be physiologically neutral, is incidentally used in medicine as a cation carrier, but not as a therapeutically active substance. In this review we discuss the results of our recent research with available literature and suggest that gluconate may be useful in the treatment of cancer.
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Publication type Article: Journal article
Document type Review
Keywords Cancer Metabolism ; Citrate ; Gluconate ; Metabolic Targeting ; Transporter; Sodium Stibogluconate; Magnesium Infusions; Phase-ii; In-vitro; Disulfiram; Prevention; Antimony; Calcium; Cells; Immunotherapy
Language
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 2234-943X
e-ISSN 2234-943X
Journal Frontiers in Oncology
Quellenangaben Volume: 9, Issue: , Pages: , Article Number: 522 Supplement: ,
Publisher Frontiers
Publishing Place Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Reviewing status Peer reviewed
Institute(s) Molekulare Endokrinologie und Metabolismus (MEM)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-505600-003
DOI 10.3389/fonc.2019.00522
WOS ID WOS:000472166900003
Scopus ID 85068970627
PubMed ID 31275855
PubMed ID PMC6593216
Erfassungsdatum 2019-07-10
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