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Determining dose enhancement factors of high-Z nanoparticles from simulations where lateral secondary particle disequilibrium exists.
Phys. Med. Biol. 64:155016 (2019)
Nanoparticles (NPs) containing high atomic number (high-Z) materials have been shown to enhance the radiobiological effectiveness of ionizing radiation. This effect is often attributed to an enhancement of the absorbed dose in the vicinity of the NPs, based on Monte Carlo simulations that show a significant local enhancement of the energy deposition on the microscopic scale. The results of such simulations may be significantly biased and lead to a severe overestimation of the dose enhancement if the condition of secondary particle equilibrium is not met in the simulation setup. This current work shows an approach to estimate a 'realistic' dose enhancement from the results of such biased simulations which is based on published photon interaction data and provides a way for correcting biased results.
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Times Cited
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1.385
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Dose Enhancement ; Gold Nanoparticles ; High-z Nanoparticles ; Monte Carlo Simulation ; Secondary Electron Equilibrium; Monte-carlo-simulation; Gold Nanoparticles; Radiation; Radiotherapy; Brachytherapy
Language
Publication Year
2019
HGF-reported in Year
2019
ISSN (print) / ISBN
0031-9155
e-ISSN
1361-6560
Journal
Physics in Medicine and Biology
Quellenangaben
Volume: 64,
Issue: 15,
Article Number: 155016
Publisher
Institute of Physics Publishing (IOP)
Publishing Place
Bristol
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Medicine (IRM)
POF-Topic(s)
30203 - Molecular Targets and Therapies
Research field(s)
Radiation Sciences
PSP Element(s)
G-501391-001
WOS ID
WOS:000480292700011
Scopus ID
85071189785
PubMed ID
31300616
Erfassungsdatum
2019-07-24