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Klepac, K. ; Georgiadi, A. ; Tschöp, M.H. ; Herzig, S.

The role of brown and beige adipose tissue in glycaemic control.

Mol. Aspects Med. 68, 90-100 (2019)
Postprint DOI PMC
Open Access Green
For the past decade, brown adipose tissue (BAT) has been extensively studied as a potential therapy for obesity and metabolic diseases due to its thermogenic and glucose-consuming properties. It is now clear that the function of BAT goes beyond heat production, as it also plays an important endocrine role by secreting the so-called batokines to communicate with other metabolic tissues and regulate systemic energy homeostasis. However, despite numerous studies showing the benefits of BAT in rodents, it is still not clear whether recruitment of BAT can be utilized to treat human patients. Here, we review the advances on understanding the role of BAT in metabolism and its benefits on glucose and lipid homeostasis in both humans and rodents. Moreover, we discuss the latest methodological approaches to assess the contribution of BAT to human metabolism as well as the possibility to target BAT, pharmacologically or by lifestyle adaptations, to treat metabolic disorders.
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Publication type Article: Journal article
Document type Review
Keywords Brown Adipose Tissue ; Glucose Homeostasis ; Lipid Homeostasis ; Clinical And Basic Science Research ; Antiobesity Therapies ; Batokines; Energy-expenditure; Insulin Sensitivity; Glucose-uptake; Fat Thermogenesis; White Fat; Nonshivering Thermogenesis; Alternative Activation; Infrared Thermography; Metabolic Homeostasis; Lipid-metabolism
Language
Publication Year 2019
HGF-reported in Year 2019
ISSN (print) / ISBN 0098-2997
e-ISSN 0098-2997
Journal Molecular Aspects of Medicine
Quellenangaben Volume: 68, Issue: , Pages: 90-100 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Radarweg 29, 1043 Nx Amsterdam, Netherlands
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
Institute of Diabetes and Obesity (IDO)
POF-Topic(s) 90000 - German Center for Diabetes Research
30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-251
G-501900-252
G-502200-001
DOI 10.1016/j.mam.2019.07.001
WOS ID WOS:000482103700008
Scopus ID 85068845257
PubMed ID 31283940
Erfassungsdatum 2019-07-24
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