PuSH - Publication Server of Helmholtz Zentrum München: IL-7-dependent compositional changes within the gamma delta T cell pool in lymph nodes during ageing lead to an unbalanced anti-tumour response.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Chen, H.C.* ; Eling, N.* ; Martinez Jimenez, C.P. ; O'Brien, L.M.* ; Carbonaro, V.* ; Marioni, J.C.* ; Odom, D.T.* ; de la Roche, M.*

IL-7-dependent compositional changes within the gamma delta T cell pool in lymph nodes during ageing lead to an unbalanced anti-tumour response.

EMBO Rep. 20:e47379 (2019)

Publ. Version/Full Text

Research data

DOI

PMC

	Open Access Hybrid

Abstract
Metrics
Extra information

How the age-associated decline of immune function leads to increased cancer incidence is poorly understood. Here, we have characterised the cellular composition of the gamma delta T-cell pool in peripheral lymph nodes (pLNs) upon ageing. We find that ageing has minimal cell-intrinsic effects on function and global gene expression of gamma delta T cells, and gamma delta TCR diversity remains stable. However, ageing alters TCR delta chain usage and clonal structure of gamma delta T-cell subsets. Importantly, IL-17-producing gamma delta 17 T cells dominate the gamma delta T-cell pool of aged mice-mainly due to the selective expansion of V gamma 6(+) gamma delta 17 T cells and augmented gamma delta 17 polarisation of V gamma 4(+) T cells. Expansion of the gamma delta 17 T-cell compartment is mediated by increased IL-7 expression in the T-cell zone of old mice. In a Lewis lung cancer model, pro-tumourigenic V gamma 6(+) gamma delta 17 T cells are exclusively activated in the tumour-draining LN and their infiltration into the tumour correlates with increased tumour size in aged mice. Thus, upon ageing, substantial compositional changes in gamma delta T-cell pool in the pLN lead to an unbalanced gamma delta T-cell response in the tumour that is associated with accelerated tumour growth.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

8.383

1.282