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Phillips, A.* ; Heier, M. ; Strobl, R.* ; Linkohr, B. ; Holle, R. ; Peters, A. ; Grill, E.*

Exposure to anticholinergic and sedative medications using the Drug Burden Index and its association with vertigo, dizziness and balance problems in older people - Results from the KORA-FF4 Study.

Exp. Gerontol. 124:110644 (2019)
Postprint DOI PMC
Open Access Green
Aims: This study examines exposure to anticholinergic and sedative (AS) medications in the general aging population using the Drug Burden Index (DBI) and to analyze the association of AS burden with vertigo, dizziness and balance problems (VDB, primary outcome) and falls (secondary outcome).Methods: We performed a cross-sectional analysis of data from the second follow-up (FF4) in 2013/14 of the Cooperative Health Research in the Region of Augsburg (KORA)-S4 study. AS burden was classified as DBI > 0. Self-reported data of VDB and falls during the previous 12 months were collected. Multivariable logistic regression was used to estimate the association of AS burden with VDB and falls.Results: 883 participants were included in this study (mean age 73.8 years, 48.4% female). AS burden was present in 167 (18.9%) participants, with the highest prevalence in those aged >= 80 years old (26.3%). In the adjusted analysis, AS burden was independently and significantly associated with VDB (Adjusted Odds Ratio (AOR): 1.73 [95% CI: 1.16, 2.56]).Conclusion: This study provides reliable prevalence estimates of AS burden in older people using the DBI in Germany, also indicating a positive and significant association with VDB. As VDB are among the main reasons for falls, we do recommend including the AS burden calculation as routine risk assessment in ambulatory medical care.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Drug Burden Index ; Anticholinergic ; Sedative ; Dizziness ; Vertigo; Functional Burden; Health; Prevalence; Adults; Falls; Risk; Prescriptions; Disability; Medicines; Validity
ISSN (print) / ISBN 0531-5565
e-ISSN 0531-5565
Journal Experimental Gerontology
Quellenangaben Volume: 124, Issue: , Pages: , Article Number: 110644 Supplement: ,
Publisher Elsevier
Publishing Place The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)
Institute of Health Economics and Health Care Management (IGM)