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Adhering to adhesion: Assessing integrin conformation to monitor T cells.
Cancer Immunol. Immunother. 68, 1855-1863 (2019)
Monitoring T cells is of major importance for the development of immunotherapies. Recent sophisticated assays can address particular aspects of the anti-tumor T-cell repertoire or support very large-scale immune screening for biomarker discovery. Robust methods for the routine assessment of the quantity and quality of antigen-specific T cells remain, however, essential. This review discusses selected methods that are commonly used for T-cell monitoring and summarizes the advantages and limitations of these assays. We also present a new functional assay, which specifically detects activated beta(2) integrins within a very short time following CD8(+) T-cell stimulation. Because of its unique and favorable characteristics, this assay could be useful for implementation into our T-cell monitoring toolbox.
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Publication type
Article: Journal article
Document type
Review
Keywords
T Cell ; Adhesion ; Function ; Immunomonitoring ; Immunotherapy ; Pivac 2018; Quality-assurance; Assay; Panel; Harmonization; Optimization; Lymphocytes; Enumeration; Guidelines; Receptors; Multimers
ISSN (print) / ISBN
0340-7004
e-ISSN
1432-0851
Journal
Cancer Immunology, Immunotherapy
Quellenangaben
Volume: 68,
Issue: 11,
Pages: 1855-1863
Publisher
Springer
Publishing Place
233 Spring St, New York, Ny 10013 Usa
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Reviewing status
Peer reviewed